The Osborn Penthouse is the home of the wealthy Osborn family.
Located in New York City, the Osborn Penthouse was where Norman and Emily Osborn raised their son Harry. However, Emily died during Harry's infancy. After Norman drank the Goblin Serum, he became periodically insane and built the Goblin Lair behind a mirror in the main sitting room. After Norman impaled himself his body was brought back to the house by Spider-Man.
Harry continued living there after his father's Death and became obsessed with revenge against on Spider-Man. He was attacked there by Doctor Octopus and made a deal to give him tritium in exchange for bringing Spider-Man there alive. Doctor Octopus captured Spider-Man and Harry took off his mask only to find out it was Peter. Later, a vision of Norman appeared in the sitting room mirror demanding Harry to avenge his death. Harry refuses and throws a glass at the mirror, shattering it and revealing to him the goblin lair.
Harry eventually used the goblin serum on himself and used some gear of his father's to try and kill Spider-Man. In the fight, Harry was knocked out and suffered from temporary amnesia. While feeling lonely, Mary Jane Watson, rang Harry to see if she could come and visit. While there, the two shared a kiss on an impulse, resulting in Mary Jane leaving and awakening Harry's memories of Peter as Spider-Man.
While under the influence of the symbiote, Spider-Man arrived at Harry's home and attacked him. The fight spilled over into the goblin lair where Harry was caught in the blast of a Pumpkin Bomb leaving him with facial burns. Eventually, Harry's butler, Bernard Houseman, told Harry that Norman died of his own hand and Spider-Man did not kill him resulting in Harry to answer Peter's pleas to help him rescue Mary Jane from Venom and The Sandman.